HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Blackmore, C. G. M. Articles by Grimstad, P. R. Search for Related Content PubMed PubMed Citation Articles by Blackmore, C. G. M. Articles by Grimstad, P. R.

¹ Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana USA 46556
³ Corresponding author (email: Carina_Blackmore{at}doh.state.fl.us)

ABSTRACT:   To evaluate the importance of eastern cottontails (Sylvilagus floridanus) as amplifying hosts for Cache Valley virus (CVV), we tested hunter-provided blood samples from northern Indiana for specific neutralizing (N) antibodies against this mosquito-borne bunya-virus. Samples were collected during the winter of 1994–95. Two seronegative eastern cottontails, captured in July 1995, were also infected with CVV by subcutaneous inoculation, and two others were infected by allowing CVV-infected mosquitoes to feed on them. The results indicate that eastern cottontails probably are not important amplifying hosts for CVV. The prevalence of N antibodies against CVV was low (6.0%, n=82) among the hunter-killed animals. Low viremia (<1.8 log₁₀ plaque-forming units/ml) of short duration (1–3 days) were seen in three of four experimentally infected eastern cottontails. The viremias were insufficient for infecting Coquillettidia perturbans, a mosquito species commonly found naturally infected with CVV.
  Key words:  Bunyaviridae, Cache Valley virus, Orthobunyavirus, serology, Sylvilagus floridanus.

² Current address: Florida Department of Health, 4052 Bald Cypress Way Bin A-08 Tallahassee, Florida 32399