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Journal of Wildlife Diseases, 42(3), 2006, pp. 677-684
© Wildlife Disease Association  2006
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SHORT COMMUNICATION

Intracytoplasmic Inclusions in Circulating Leukocytes from an Eastern Box Turtle (Terrapene carolina carolina) with Iridoviral Infection

Matthew C. Allender1,5,6, Michael M. Fry2, Armando R. Irizarry3, Linden Craig2, April J. Johnson4 and Michael Jones2

1 University of Illinois, College of Veterinary Medicine, 2001 South Lincoln Ave., Urbana, Illinois 61802, USA;
2 University of Tennessee, College of Veterinary Medicine, 2407 River Dr., Knoxville, Tennessee 37996, USA;
3 Eli Lilly and Company, Lilly Research Laboratories, PO Box 708, Greenfield, Indiana 46140, USA;
4 University of Florida, College of Veterinary Medicine, PO Box 100126, Gainesville, Florida 32608, USA
6 Corresponding author: (email: mattallender{at}yahooom)

ABSTRACT:   A free-ranging adult female eastern box turtle (Terrapene carolina carolina) was presented to the University of Tennessee in October 2003 because of suspected trauma and blindness. Physical examination revealed lethargy, clear ocular and nasal discharges, and white oral and laryngeal plaques. Intracytoplasmic inclusions within heterophils and large mononuclear leukocytes were observed on routine blood smear examination. Postmortem findings included necrosis of epithelial and parenchymal cells with intracytoplasmic inclusions. Ultrastructurally, the leukocyte inclusions consisted of variably electron-dense granular material and viral particles consistent with the Iridoviridae family of viruses. The virus shared 100% sequence identity to a 420-base pair sequence of frog virus 3 (family Iridoviridae, genus Ranavirus) as determined by polymerase chain reaction and gene sequencing targeting a portion of the Ranavirus major capsid protein gene.
  Key words:  Electron microscopy, frog virus 3, intracytoplasmic inclusion, iridovirus, leukocyte, PCR, Ranavirus, Terrapene carolina.

5 Current address: University of Tennessee, College of Veterinary Medicine, 2001 South Lincoln Ave, Urbana, Illinois, 61802, USA




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