JWD Your personal alerts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Journal of Wildlife Diseases, 42(1), 2006, pp. 23-32
© Wildlife Disease Association  2006
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nollens, H. H.
Right arrow Articles by Condit, R. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nollens, H. H.
Right arrow Articles by Condit, R. C.

PATHOLOGY AND PRELIMINARY CHARACTERIZATION OF A PARAPOXVIRUS ISOLATED FROM A CALIFORNIA SEA LION (ZALOPHUS CALIFORNIANUS)

Hendrik H. Nollens1,7, Elliott R. Jacobson1, Frances M. D. Gulland2, Diedrich O. Beusse1, Gregory D. Bossart3, Jorge A. Hernandez4, Paul A. Klein5 and Richard C. Condit6

1 Marine Mammal Health Program and Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, PO Box 100126, Gainesville, Florida 32610, USA
2 The Marine Mammal Center, 1065 Fort Cronkhite, Sausalito, California 94965, USA
3 Division of Marine Mammal Research and Conservation, Harbor Branch Oceanographical Institution, 5600 US 1 North, Ft. Pierce, Florida 34946, USA
4 Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, PO Box 100126, Gainesville, Florida 32610, USA
5 Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, PO Box 100275, Gainesville, Florida 32610, USA
6 Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, PO Box 100266, Gainesville, Florida 32610, USA
7 Corresponding author (email: NollensH{at}mail.vetmed.ufl.edu)

ABSTRACT:   Cutaneous pox-like lesions are a common complication in the rehabilitation of pinnipeds. However, the exact identity, taxonomy, and host range of pinniped parapoxviruses remain unknown. During a poxvirus outbreak in May 2003 in California sea lions (Zalophus californianus) at a marine mammal rehabilitation facility, multiple raised, firm, 1–3-cm skin nodules from the head, neck, and thorax of one sea lion weanling pup that spontaneously died were collected. Histologically, the nodules were characterized by inflammation and necrosis of the dermis and epidermis, acanthosis, and ballooning degeneration of the stratum spinosum. Large, coalescing eosinophilic cytoplasmic inclusions were observed in the ballooned cells. A parapoxvirus (sea lion poxvirus 1, SLPV-1) was isolated on early passage California sea lion kidney cells inoculated with a tissue homogenate of a skin nodule. The morphology of the virions on electron microscopy was consistent with that of parapoxviruses. Partial sequencing of the genomic region encoding the putative major virion envelope antigen p42K confirmed the assignment of the sea lion poxvirus to the genus Parapoxvirus. Although SLPV-1 is most closely related to the poxvirus of harbor seals of the European North Sea, it is significantly different from orf virus, bovine papular stomatitis virus, pseudocowpox virus and the parapoxvirus of New Zealand red deer.
  Key words:  California sea lion, isolation, pathology, pinniped, poxvirus, virus, Zalophus californianus.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the Wildlife Disease Association.