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Journal of Wildlife Diseases, 40(3), 2004, pp. 429-433
© Wildlife Disease Association  2004
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SAFETY OF BRUCELLA ABORTUS STRAIN RB51 IN BLACK BEARS

Steven C. Olsen1,5, Jack Rhyan2, T. Gidlewski3, Jesse Goff4 and W. C. Stoffregen1

1 Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Ames, Iowa 50010, USA
2 National Wildlife Research Center, Animal and Plant Health Inspection Service, Veterinary Services, US Department of Agriculture, Fort Collins, Colorado 80521, USA
3 Pathology Laboratory, Animal and Plant Health Inspection Service, Veterinary Services, US Department of Agriculture, Ames, Iowa 50010, USA
4 Metabolic Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Ames, Iowa 50010, USA
5 Corresponding author (email: solsen{at}nadc.ars.usda.gov)

In two studies conducted from October 1999 to March 2000 and December 2000 to April 2001, adult black bears (Ursus americanus) were orally inoculated with 1.4–3.1x1010 colony-forming units (CFU) of Brucella abortus strain RB51 (SRB51, n=12) or 2 ml of 0.15 M NaCl solution (saline, n=11). We did not detect a difference (P>0.05) in antibody titers to SRB51 in serum obtained before vaccination, at 8 wk after vaccination, or at necropsy at 21 or 23 wk after vaccination between SRB51-vaccinated and nonvaccinated bears. The SRB51 vaccine strain was recovered from tissues obtained at necropsy from one of six SRB51-vaccinated bears in study 1, but none of the six SRB51-vaccinated bears in study 2. Vaccination of black bears with SRB51 did not appear to influence (P>0.05) reproductive performance.

  Key words:  Biosafety, Brucella, RB51, serology, Ursus americanus, vaccine.






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