JWD Subscribe to eTOC alerts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Journal of Wildlife Diseases, 32(3), 1996, pp. 417-423
© Wildlife Disease Association  1996
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Williams, E.
Right arrow Articles by Appel, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Williams, E.
Right arrow Articles by Appel, M.

Vaccination of black-footed ferret (Mustela nigripes) x Siberian polecat (M. eversmanni) hybrids and domestic ferrets (M. putorius furo)against canine distemper

ES Williams, SL Anderson, J Cavender, C Lynn, K List, C Hearn, and MJ Appel


ABSTRACT

An inactivated canine distemper vaccine with adjuvant and a modified-live virus (MLV) vaccine were evaluated using black-footed ferret (Mustegla nigripes) x Siberian polecat (Mustela eversmanni) hybrids us surrogates for endangered black-footed ferrets. For comparative purposes, we also vaccinated domestic ferrets (Mustela putorius furo) with the MLV vaccine. Response to vaccination was measured by clinical observation, hematology, dynamics of serum virus neutralizing antibodies, and challenge with virulent canine distemper virus. No clinical signs attributable to the vaccines were observed. Transient leukopenia occurred in hybrid ferrets that received MLV vaccine and there was marked lymphopenia for approximately 52 days post-vaccination. Lymphopenia was present for approximately 21 days in domestic ferrets vaccinated with MLV vaccine. Neutralizing antibodies against canine distemper virus were detected 14 days post-vaccination in hybrids receiving MLV vaccine and most titers were > 1:1024 for the 791 days of the study. Antibody titers in hybrids vaccinated with the inactivated vaccine were significantly lower. All eight hybrid ferrets that received MLV vaccine survived challenge with virulent canine distemper virus without clinical disease. However, one of seven hybrids vaccinated with the inactivated vaccine developed canine distemper and was euthanized; two other hybrids became clinically ill but survived. The MLV vaccine may be useful in prevention of canine distemper in black-footed ferrets, but until additional studies of efficacy and safety are completed, use of the inactivated vaccine is appropriate.


This article has been cited by other articles:


Home page
 jvmeHome page
L. J. Lowenstine and R. J. Montali
Historical Perspective and Future Directions in Training of Veterinary Pathologists with an Emphasis on Zoo and Wildlife Species
J Vet Med Educ, January 1, 2006; 33(3): 338 - 345.
[Abstract] [Full Text] [PDF]

Home page
 J Wildl DisHome page
F. Cirone, G. Elia, M. Campolo, K. Friedrich, V. Martella, A. Pratelli, and C. Buonavoglia
Immunogenicity of an Inactivated Oil-Emulsion Canine Distemper Vaccine in African Wild Dogs
J. Wildl. Dis., April 1, 2004; 40(2): 343 - 346.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
J. F. Evermann, C. W. Leathers, J. R. Gorham, A. J. McKeirnan, and M. J. G. Appel
Pathogenesis of Two Strains of Lion (Panthera leo) Morbillivirus in Ferrets (Mustela putorius furo)
Vet. Pathol., May 1, 2001; 38(3): 311 - 316.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by the Wildlife Disease Association.