Between 1980 and 1994, 586 individuals of 20 native reptile and amphibian species were evaluated at a wildlife rehabilitation facility in DuPage County, Illinois (USA). On examination, 48% of reptiles and 52% of amphibians were injured, and 2% of each class were diseased; remaining animals were uninjured. The most frequent causes of injury to reptiles were automobile collisions (55%), ingestion of fishing tackle (19%), and domestic animal attacks (8%). Automobile collisions (38%), lawn and garden accidents (33%), and pet collection (19%) were the most frequent causes of injury to amphibians. We released 354 reptiles and 54 amphibians into appropriate habitat available in local forest preserves, representing case release prevalences of 84% and 68% for each class, respectively.