An outbreak of avian pox, with an estimated 12-fold increase in the incidence of infection, occurred among wild bobwhites (Colinus virginianus) in the southwestern Georgia/northcentral Florida region. The outbreak was first detected in July, 1978, and continued at least until March, 1979. During this period, 26 separate clinical case accessions involving 43 bobwhites from 8 counties in Florida and Georgia were diagnosed as avian pox. A survey of 2,586 bobwhites from 6 southeastern states revealed avian pox infections in 312 bobwhites from Florida, Georgia, North Carolina, and Tennessee. Seventy-seven percent of the infected birds in the survey had only mild lesions on the legs and feet; however, 23% had more extensive lesions on the head. Severely affected birds had lesions around the eyes, nares, and in the mouth which impaired vision, respiration, and/or feeding. Infection rates were not related to age or sex of the birds but varied greatly among locales, even on adjoining properties. A morbidity rate of approximately 2% and a mortality rate between 0.6 and 1.2% were estimated for a 13,000 km2 region in Georgia and Florida.