Spontaneous vulvovaginitis erupted in wildebeest (Connochaetes taurinus) after betamethasone inoculation. Infectious bovine rhinotracheitis/infectious pustular vulvovaginitis (IBR/IPV) is probably a venereal disease because virgin wildebeest did not develop vulvovaginitis after betamethasone injections, nor was the virus transmitted to these virgin wildebeest and steers which were in pen contact with the affected animals. A domestic bovine heifer developed mild IPV and became a virus carrier, when exposed to the wildebeest IPV virus by vaginal instillation.