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OBSERVATIONS ON BLUETONGUE AND EPIZOOTIC HEMORRHAGIC DISEASE VIRUSES IN WHITE-TAILED DEER: (1) DISTRIBUTION OF VIRUS IN THE BLOOD (2) CROSS-CHALLENGE
1 Department of Veterinary Science, University of Wisconsin, Madison, Wisconsin 53706, U.S.A.
2 Dean, College of Natural Resources, University of Wisconsin, Stevens Point, Wisconsin 54481, U.S.A.
The viruses of bluetongue and epizootic hemorrhagic disease produced cell associated viremias in white-tailed deer (Odocoileus virginianus). Highest virus titers were associated with the erythrocytes. The titers of virus in the erythrocyte fraction of blood were consistently higher than those in the leukocyte fraction, although virus persisted in both fractions for approximately the same length of time. All detectable viremia disappeared within 6 to 8 days following the development of virus-specific neutralizing antibodies. These antibodies failed to confer protection against challenge with virulent heterologous virus, although the time of death was delayed 3 to 11 days in comparison with control deer.
Submitted on July 16, 1973
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